NederlandsMicrodosing with LSD analogue 1cP-LSD
LSD we probably all know. For decades, this potent psychedelic drug has been loved by psychonauts and microdosers alike. But have you ever heard of 1cP-LSD? Here's why 1cP-LSD can be a great alternative to LSD for microdosing.
Microdosing with LSD analogue 1cP-LSD
Who is who in the LSD family?
1cP-LSD or 1-Cyclopropionyl-lysergic acid diethylamide is a derivative of 1P-LSD. It is also a pro-drug for LSD-25. This means that the substance is converted to LSD through metabolism in the human body.
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In July 2019, 1P-LSD was banned in Germany through an update to the New Psychoactive Substances Act (NpSG). At the time, 1P-LSD was the most popular LSD pro-drug. However, this vacuum was soon filled by 1cP-LSD entering the market. This just goes to show that drug use cannot be prevented by prohibition. But why is one substance banned and not the other? And what is the difference?
The difference between 1cP-LSD and LSD
In short, you could describe the difference between 1cP-LSD and LSD as follows. LSD is completely "finished," whereas with 1cP-LSD - as well as other derivatives such as 1P and 1B - human metabolism is used to convert the substance into LSD. This is called pro-drug. It may take a little longer for the body to convert the substance into LSD, but subsequently, there is no difference in its effects. LSD is LSD, whether you ingest it as LSD, or when you let your body turn it into LSD.
In fact, the biggest difference is that the distribution and sale of LSD is quite often tampered with. In some cases it is not evenly distributed on the blotter, the amount is incorrect, or sometimes it even turns out not to be LSD at all. This makes consuming LSD risky. If you want to use LSD, make sure to always get it tested, or test it yourself with an LSD test kit.
This problem doesn’t occur when looking at legal LSD derivatives. They are available online, reliable, and you don't need a test kit. In terms of potency, 1cP-LSD is most similar to LSD-25. 1P-LSD is slightly lighter, and 1B-LSD is an even lighter variant. 1B is therefore offered as a trip dosage of 125 micrograms, while with 1cP-LSD 100 micrograms guarantee a strong trip - or ten to fifteen microdoses.
Like many other research chemicals, 1cP-LSD is still a very new substance. Therefore, there is no complete certainty about the risks of this substance. We assume that 1cP-LSD works in the same way as 1P-LSD and LSD and that they behave the same after conversion in our bodies.
What does the developer say about 1cP-LSD?
"If you look at substances and their metabolism (breakdown pathways/transformation in the body) of other substances with a cyclopropyl group, for example, Naltrexone or Buprenorphine, you will see that the group is also split off over time. In both cases, however, you don't have a carbonyl. So, I think LSD is formed at some point, but I suspect that 1cp LSD is not a pure prodrug, but can also activate the receptors themselves. Corresponding research will reveal this in the future."
2 methods of microdosing with 1cP-LSD
- 1cP Microdose: ready-to-use in a 10 milliliter pipette bottle
- 1cp-LSD blotters of 20 micrograms: cut these into 4 triangles of 5 mcg each.
- 1cP-LSD pellets of 10 micrograms.
Scientific study of 1cP-LSD
On March 16, 2020, a scientific study was published that examined the conversion of 1cP-LSD into LSD. It was conducted by a working group in California, which had already examined many other LSD analogues, led by Professor Halberstadt. The scientists dissolved 1cP-LSD in human blood serum and noted that it was converted to LSD. They also examined the response of mice to 1cP LSD. The mice showed the same "head twitches" (a back and forth shaking of the head) as seen with LSD in mice - at the same dosage. The researchers concluded that 1cP-LSD is an LSD prodrug, but that further clinical studies are needed to investigate the profile and potency of 1cP-LSD.
As 1cP-LSD is converted to LSD in the body, it is coupled to the 5HT2A serotonin receptors in the brain. These receptors are found primarily in the prefrontal cortex of our brain, which is involved in our cognitive planning, personality, decision-making and social behavior. This part of the brain is also called the "Default Mode Network" (DMN) because it is turned on when we are not focusing on anything in particular - our brain's default mode of operation.
The serotonin receptors are slowed down by the 1cP-LSD, which significantly limits their ability to communicate. This leads to the well-known "dissolution of personality" of 1cP-LSD - the DMN becomes increasingly irrelevant and moves into the background. The other brain regions seem to benefit from this because they are given more resources and opportunities to communicate with each other.
These sometimes chaotic connections can lead to effects such as synesthesia (the fusion of the senses: tasting colour, seeing music) and new insights and perspectives. The disorder in the brain is magnified to the point of increasing the likelihood of personality change, as shown in this 2016 study.
Toxicity of 1cP-LSD
The long-term toxicity and health effects of 1cP-LSD have not been studied. This is because 1cP-LSD is a Research Chemical that has almost no history of human use - it has only been on the market since June 2019.
However, as with LSD and psychedelics in general, 1cP-LSD can trigger latent psychosis. In general, we do not recommend that people with a history of mental illness use this substance, especially if they are outside of a controlled medical environment.
Risks and hazards of 1cP-LSD
As mentioned above, there has been no proven death from the use of LSD to date. In addition, there are no known long-term side effects of LSD.
At this time, we cannot say if the same applies to the prodrug 1cP-LSD, as it has not been studied enough. So far, all studies indicate that 1cP-LSD is no more dangerous than LSD or 1P-LSD, but we cannot say this with 100 percent certainty. In any case, it seems to have the same risk profile as LSD.
Is 1cP-LSD legal?
1cP-LSD is a relatively new psychoactive drug and has only been on the market since January 2020. Like other 'Research Chemicals', it does not yet fall under the 'New Psychoactive Substances Act' (NpSG). However, sooner or later it will likely be included. Even with substances covered by the NpSG, consumption or possession is not penalized - purchasing it, however, is.
Overall, it must be said that the subject is quite controversial. There is virtually no one hundred per cent agreement on the legal status of 1cP-LSD.
Unfortunately, the German NpSG amendment will be enforced on the 3rd July 2021, banning 1cP-LSD and many other compounds. This ban comes a little earlier than anticipated based on the amendments of previous years.
New alternative analogue 1V-LSD
We are very excited to announce the release of 1V-LSD (1-valeroyl-lysergic acid diethylamide hemi-L-tartrate) or simply ‘Valerie’. 1V-LSD is a prodrug of LSD and a homologue of 1P-LSD. Since it is a prodrug, it shares many similar properties with LSD itself but also 1P-LSD, 1cP-LSD, and 1B-LSD. However, Valerie also has some distinguishing features including increased visual effects compared to 1cP-LSD and 1P-LSD, as reported by our research group.
The nickname ‘Valerie’ is derived from segments of the most significant chemical groups described in the chemical name 1-valeroyl-lysergic acid diethylamide. Several participants of our research group also noted the presence of a ‘female entity’ whilst researching this compound. Hence we feel the name Valerie is apt!
1V-LSD is the N-valeroyl derivative of LSD. Due to the high lipophilicity of the valeroyl group there is now a great opportunity to study the potentially unique pharmacokinetic properties of this novel compound.
Valerie was created with global NPS legislation in mind; this beautiful molecule is completely legal in almost all countries, including Germany!
Given that 1V-LSD has a slightly higher mass than other prodrugs, we have decided to increase the dosage of our standard blotters. We will be offering 1V-LSD 150mcg Blotters as our standard product, and in the future introduce pellets, extra dosed blotters, and powder. Based on our tests, 150mcg of 1V-LSD is about equivalent to 125mcg of 1cP-LSD. Therefore, our standard 1V-LSD blotters are stronger than our standard 1cP-LSD blotters — please inform end users accordingly!
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Safer/responsible use of 1cP-LSD
There are a few things you can keep in mind if you want to microdose with 1cP-LSD to make your experience as safe as possible.
- Only take a 1cP Microdose when you’re properly prepared. Make sure the set and setting and dose are correct.
- When microdosing, it is best to consume 1cP-LSD in the morning due to the long duration of the effect of the microdose.
- The full effect of 1cP-LSD only develops about 2 hours after ingestion.
Combining 1cP-LSD with other drugs?
In general, we do not recommend combining 1cP-LSD with other substances. It creates such a powerful effect that all of your senses and abilities are affected. If you add other substances, it can diminish the profound experience of 1cP-LSD itself.
Conclusion
Because this drug is still so new, not a whole lot is known about 1cP-LSD - aside from the fact that 1cP-LSD is considered more powerful than LSD according to many users. As with LSD, there appears to be no toxicity and a low risk of mental health issues. Having said that, if you know certain mental issues, such as schizophrenia are prevalent in your family, it is best to avoid psychedelics, or at the very least, be very careful.
Important: as with all research chemicals, these substances are intended for research purposes, not for human consumption. This means that the Commodities Act has not approved these substances for consumption. This also applies to LSD and 1P-LSD.
More information about microdosing with 1cP-LSD?
Our friends at Microdosing Institute have written a clear page explaining microdosing with LSD analogues.
Sources:
https://psychonautwiki.org/wiki/Talk:1cP-LSD